Geoffrey D Keeler

Geoffrey D Keeler,

Research Assistant Professor

Department: MD-PEDS-CELL / MOLEC THERP DIV
Business Phone: (352) 273-8258
Business Email: gkeeler@ufl.edu

Publications

2021
AAV3-miRNA vectors for growth suppression of human hepatocellular carcinoma cells in vitro and human liver tumors in a murine xenograft model in vivo.
Gene therapy. 28(7-8):422-434 [DOI] 10.1038/s41434-020-0140-1. [PMID] 32152434.
2020
Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing.
Molecular therapy. Nucleic acids. 20:451-458 [DOI] 10.1016/j.omtn.2020.03.009. [PMID] 32276210.
2020
Type I IFN Sensing by cDCs and CD4+ T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8+ T Cells.
Molecular therapy : the journal of the American Society of Gene Therapy. 28(3):758-770 [DOI] 10.1016/j.ymthe.2019.11.011. [PMID] 31780366.
2019
Liver induced transgene tolerance with AAV vectors.
Cellular immunology. 342 [DOI] 10.1016/j.cellimm.2017.12.002. [PMID] 29576315.
2018
Gene Therapy-Induced Antigen-Specific Tregs Inhibit Neuro-inflammation and Reverse Disease in a Mouse Model of Multiple Sclerosis.
Molecular therapy : the journal of the American Society of Gene Therapy. 26(1):173-183 [DOI] 10.1016/j.ymthe.2017.09.001. [PMID] 28943274.
2016
Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.
Molecular therapy : the journal of the American Society of Gene Therapy. 24(6):1042-1049 [DOI] 10.1038/mt.2016.61. [PMID] 27019999.
2015
Effects of delayed delivery of dexamethasone-21-phosphate via subcutaneous microdialysis implants on macrophage activation in rats.
Acta biomaterialia. 23:27-37 [DOI] 10.1016/j.actbio.2015.05.011. [PMID] 25985913.
2015
Localized delivery of dexamethasone-21-phosphate via microdialysis implants in rat induces M(GC) macrophage polarization and alters CCL2 concentrations.
Acta biomaterialia. 12:11-20 [DOI] 10.1016/j.actbio.2014.10.022. [PMID] 25449921.
2014
Comparison of microdialysis sampling perfusion fluid components on the foreign body reaction in rat subcutaneous tissue.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 57:60-7 [DOI] 10.1016/j.ejps.2013.11.005. [PMID] 24239995.

Grants

Dec 2018 – Nov 2019
Identifying optimal CD8 Treg for CAR Treg Therapy
Role: Principal Investigator
Funding: AMERICAN SOCIETY OF GENE AND CELL THERAP

Teaching Profile

Courses Taught
2020-2021
GMS6253 Molecular Therapy III ? Immunology of Gene Transfer

Contact Details

Phones:
Business:
(352) 273-8258
Emails:
Business:
gkeeler@ufl.edu